Ontology highlight
ABSTRACT:
SUBMITTER: Tachibana M
PROVIDER: S-EPMC3561483 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Nature 20121024 7434
Mutations in mitochondrial DNA (mtDNA) are associated with severe human diseases and are maternally inherited through the egg's cytoplasm. Here we investigated the feasibility of mtDNA replacement in human oocytes by spindle transfer (ST; also called spindle-chromosomal complex transfer). Of 106 human oocytes donated for research, 65 were subjected to reciprocal ST and 33 served as controls. Fertilization rate in ST oocytes (73%) was similar to controls (75%); however, a significant portion of S ...[more]