Ontology highlight
ABSTRACT:
SUBMITTER: Ueda O
PROVIDER: S-EPMC3561642 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Ueda Otoya O Tateishi Hiromi H Higuchi Yoshinobu Y Fujii Etsuko E Kato Atsuhiko A Kawase Yosuke Y Wada Naoko A NA Tachibe Takanori T Kakefuda Mami M Goto Chisato C Kawaharada Makoto M Shimaoka Shin S Hattori Kunihiro K Jishage Kou-Ichi K
Scientific reports 20130201
For clinical trials of therapeutic monoclonal antibodies (mAbs) to be successful, their efficacy needs to be adequately evaluated in preclinical experiments. However, in many cases it is difficult to evaluate the candidate mAbs using animal disease models because of lower cross-reactivity to the orthologous target molecules. In this study we have established a novel humanized Castleman's disease mouse model, in which the endogenous interleukin-6 receptor gene is successfully replaced by human IL ...[more]