Ontology highlight
ABSTRACT:
SUBMITTER: Liu T
PROVIDER: S-EPMC3561713 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Liu Tong T Reyes-Caballero Hermes H Li Chenxi C Scott Robert A RA Giedroc David P DP
Biochemistry 20070908 39
Transition metal-transporting P1B-type CPx ATPases play crucial roles in mediating metal homeostasis and resistance in all cells. The degree to which N-terminal metal binding domains (MBDs) confer metal specificity to the transporter is unclear. We show that the two MBDs of the Zn/Cd/Pb effluxing pump Anabaena AztA are functionally nonequivalent, but only with respect to zinc resistance. Inactivation of the a-MBD largely abrogates resistance to high intracellular Zn(II) levels, whereas inactivat ...[more]