Ontology highlight
ABSTRACT:
SUBMITTER: Idoyaga J
PROVIDER: S-EPMC3561796 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Idoyaga Juliana J Fiorese Christopher C Zbytnuik Lori L Lubkin Ashira A Miller Jennifer J Malissen Bernard B Mucida Daniel D Merad Miriam M Steinman Ralph M RM
The Journal of clinical investigation 20130109 2
Harnessing DCs for immunotherapies in vivo requires the elucidation of the physiological role of distinct DC populations. Migratory DCs traffic from peripheral tissues to draining lymph nodes charged with tissue self antigens. We hypothesized that these DC populations have a specialized role in the maintenance of peripheral tolerance, specifically, to generate suppressive Foxp3+ Tregs. To examine the differential capacity of migratory DCs versus blood-derived lymphoid-resident DCs for Treg gener ...[more]