Ontology highlight
ABSTRACT:
SUBMITTER: Enwere EK
PROVIDER: S-EPMC3561910 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Enwere Emeka K EK Boudreault Louise L Holbrook Janelle J Timusk Kristen K Earl Nathalie N LaCasse Eric E Renaud Jean-Marc JM Korneluk Robert G RG
Human molecular genetics 20121125 5
The cellular inhibitor of apoptosis 1 (cIAP1) protein is an essential regulator of canonical and noncanonical nuclear factor κB (NF-κB) signaling pathways. NF-κB signaling is known to play important roles in myogenesis and degenerative muscle disorders such as Duchenne muscular dystrophy (DMD), but the involvement of cIAP1 in muscle disease has not been studied directly. Here, we asked whether the loss of cIAP1 would influence the pathology of skeletal muscle in the mdx mouse model of DMD. Doubl ...[more]