Ontology highlight
ABSTRACT:
SUBMITTER: Crisalli P
PROVIDER: S-EPMC3562402 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20130115 3
The formation of oximes and hydrazones is widely used in chemistry and biology as a molecular conjugation strategy for achieving ligation, attachment, and bioconjugation. However, the relatively slow rate of reaction has hindered its utility. Here, we report that simple, commercially available anthranilic acids and aminobenzoic acids act as superior catalysts for hydrazone and oxime formation, speeding the reaction considerably over the traditional aniline-catalyzed reaction at neutral pH. This ...[more]