Gene therapy for heart failure: where do we stand?
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ABSTRACT:
SUBMITTER: Naim C
PROVIDER: S-EPMC3562543 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Gene therapy for heart failure: where do we stand?
Naim Charbel C Yerevanian Armen A Hajjar Roger J RJ
Current cardiology reports 20130201 2
Advances in understanding of the molecular basis of myocardial dysfunction, together with the development of increasingly efficient gene transfer technology, has placed heart failure within reach of gene-based therapy. Multiple components of cardiac contractility, including the Beta-adrenergic system, the calcium channel cycling pathway, and cytokine mediated cell proliferation, have been identified as appropriate targets for gene therapy. The development of efficient and safe vectors such as ad ...[more]
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