Ontology highlight
ABSTRACT:
SUBMITTER: Lin CJ
PROVIDER: S-EPMC3562571 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lin Chun-Jung CJ Rao Yerra Koteswara YK Hung Chiu-Lien CL Feng Chun-Lung CL Lane Hsien-Yuan HY Tzeng David T W DT Hsu Ping-Ning PN Lai Chih-Ho CH Tzeng Yew-Min YM
Evidence-based complementary and alternative medicine : eCAM 20130108
The bacterial pathogen Helicobacter pylori (Hp) is the leading risk factor for the development of gastric cancer. Hp virulence factor, cytotoxin-associated gene A (CagA) interacted with cholesterol-enriched microdomains and leads to induction of inflammation in gastric epithelial cells (AGS). In this study, we identified a triterpenoid methylantcinate B (MAB) from the medicinal mushroom Antrodia camphorata which inhibited the translocation and phosphorylation of CagA and caused a reduction in hu ...[more]