Molecular signature of cancer at gene level or pathway level? Case studies of colorectal cancer and prostate cancer microarray data.
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ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC3562646 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
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Molecular signature of cancer at gene level or pathway level? Case studies of colorectal cancer and prostate cancer microarray data.
Chen Jiajia J Wang Ying Y Shen Bairong B Zhang Daqing D
Computational and mathematical methods in medicine 20130116
With recent advances in microarray technology, there has been a flourish in genome-scale identification of molecular signatures for cancer. However, the differentially expressed genes obtained by different laboratories are highly divergent. The present discrepancy at gene level indicates a need for a novel strategy to obtain more robust signatures for cancer. In this paper we hypothesize that (1) the expression signatures of different cancer microarray datasets are more similar at pathway level ...[more]
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