Ontology highlight
ABSTRACT:
SUBMITTER: Solimini NL
PROVIDER: S-EPMC3562831 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Solimini Nicole L NL Liang Anthony C AC Xu Chunxiao C Pavlova Natalya N NN Xu Qikai Q Davoli Teresa T Li Mamie Z MZ Wong Kwok-Kin KK Elledge Stephen J SJ
Proceedings of the National Academy of Sciences of the United States of America 20130114 5
Cancer develops through genetic and epigenetic alterations that allow unrestrained proliferation and increased survival. Using a genetic RNAi screen, we previously identified hundreds of suppressors of tumorigenesis and/or proliferation (STOP) genes that restrain normal cell proliferation. Our STOP gene set was significantly enriched for known and putative tumor suppressor genes. Here, we report a tumor-suppressive role for one STOP gene, phosphatase and actin regulator 4 (PHACTR4). Phactr4 is o ...[more]