Ontology highlight
ABSTRACT:
SUBMITTER: Higgins MK
PROVIDER: S-EPMC3562850 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Higgins Matthew K MK Tkachenko Olga O Brown Alan A Reed Jenny J Raper Jayne J Carrington Mark M
Proceedings of the National Academy of Sciences of the United States of America 20130114 5
African trypanosomes are protected by a densely packed surface monolayer of variant surface glycoprotein (VSG). A haptoglobin-hemoglobin receptor (HpHbR) within this VSG coat mediates heme acquisition. HpHbR is also exploited by the human host to mediate endocytosis of trypanolytic factor (TLF)1 from serum, contributing to innate immunity. Here, the crystal structure of HpHbR from Trypanosoma congolense has been solved, revealing an elongated three α-helical bundle with a small membrane distal h ...[more]