Ontology highlight
ABSTRACT:
SUBMITTER: Debnath B
PROVIDER: S-EPMC3563081 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Debnath Bikash B Xu Shili S Grande Fedora F Garofalo Antonio A Neamati Nouri N
Theranostics 20130115 1
CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated with several diseases, such as HIV, cancer, WHIM syndrome, rheumatoid arthritis, pulmonary fibrosis and lupus. For example, CXCR4 is one of the major co-receptors for HIV entry into target cells, while in cancer it plays an important role in tumor cell metastasis. Several promising CXCR4 antagonists have been developed to ...[more]