Ontology highlight
ABSTRACT:
SUBMITTER: Cao S
PROVIDER: S-EPMC3563091 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20120803 18
Targeting and inhibiting CMG2 (Capillary Morphogenesis Gene protein 2) represents a new strategy for therapeutic agents for cancer and retinal diseases due to CMG2's role in blood vessel growth (angiogenesis). A high throughput FRET (Förster Resonance Energy Transfer) assay was developed for the identification of CMG2 inhibitors as anti-angiogenetic agents. Bioassay-guided separation led to the isolation and identification of two new compounds (1 and 2) from CR252M, an endophytic fungus Coccomyc ...[more]