Ontology highlight
ABSTRACT:
SUBMITTER: Mazin P
PROVIDER: S-EPMC3564255 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Mazin Pavel P Xiong Jieyi J Liu Xiling X Yan Zheng Z Zhang Xiaoyu X Li Mingshuang M He Liu L Somel Mehmet M Yuan Yuan Y Phoebe Chen Yi-Ping YP Li Na N Hu Yuhui Y Fu Ning N Ning Zhibin Z Zeng Rong R Yang Hongyi H Chen Wei W Chen Wei W Gelfand Mikhail M Khaitovich Philipp P
Molecular systems biology 20130101
While splicing differences between tissues, sexes and species are well documented, little is known about the extent and the nature of splicing changes that take place during human or mammalian development and aging. Here, using high-throughput transcriptome sequencing, we have characterized splicing changes that take place during whole human lifespan in two brain regions: prefrontal cortex and cerebellum. Identified changes were confirmed using independent human and rhesus macaque RNA-seq data s ...[more]