Ontology highlight
ABSTRACT:
SUBMITTER: Estaras C
PROVIDER: S-EPMC3564542 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Estarás Conchi C Fueyo Raquel R Akizu Naiara N Beltrán Sergi S Martínez-Balbás Marian A MA
Molecular biology of the cell 20121214 3
JMJD3 H3K27me3 demethylase plays an important role in the transcriptional response to different signaling pathways; however, the mechanism by which it facilitates transcription has been unclear. Here we show that JMJD3 regulates transcription of transforming growth factor β (TGFβ)-responsive genes by promoting RNA polymerase II (RNAPII) progression along the gene bodies. Using chromatin immunoprecipitation followed by sequencing experiments, we show that, upon TGFβ treatment, JMJD3 and elongatin ...[more]