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Rapid release of plasmid DNA from polyelectrolyte multilayers: a weak poly(acid) approach.


ABSTRACT: We demonstrate an approach to the assembly of DNA-containing polyelectrolyte multilayers that can be used to promote rapid release of DNA from surfaces. The approach is based on layer-by-layer incorporation of poly(acrylic acid) to promote rapid erosion in physiologically relevant media.

SUBMITTER: Flessner RM 

PROVIDER: S-EPMC3564967 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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Rapid release of plasmid DNA from polyelectrolyte multilayers: a weak poly(acid) approach.

Flessner Ryan M RM   Yu Yan Y   Lynn David M DM  

Chemical communications (Cambridge, England) 20101123 1


We demonstrate an approach to the assembly of DNA-containing polyelectrolyte multilayers that can be used to promote rapid release of DNA from surfaces. The approach is based on layer-by-layer incorporation of poly(acrylic acid) to promote rapid erosion in physiologically relevant media. ...[more]

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