Ontology highlight
ABSTRACT:
SUBMITTER: Congrains A
PROVIDER: S-EPMC3565320 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Congrains Ada A Kamide Kei K Ohishi Mitsuru M Rakugi Hiromi H
International journal of molecular sciences 20130110 1
ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions. ANRIL has been shown to regulate its neighbor tumor suppressors CDKN2A/B by epigenetic mechanisms and thereby regulate cell proliferation and senescence. However, the clear role of ...[more]