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Blood microRNAs in low or no risk ischemic stroke patients.

ABSTRACT: Ischemic stroke is a multi-factorial disease where some patients present themselves with little or no risk factors. Blood microRNA expression profiles are becoming useful in the diagnosis and prognosis of human diseases. We therefore investigated the blood microRNA profiles in young stroke patients who presented with minimal or absence of risk factors for stroke such as type 2 diabetes, dyslipidemia and hypertension. Blood microRNA profiles from these patients varied with stroke subtypes as well as different functional outcomes (based on modified Rankin Score). These microRNAs have been shown to target genes that are involved in stroke pathogenesis. The findings from our study suggest that molecular mechanisms in stroke pathogenesis involving low or no risk ischemic stroke patients could differ substantially from those with pre-existing risk factors.

SUBMITTER: Tan JR

PROVIDER: S-EPMC3565366 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Blood microRNAs in low or no risk ischemic stroke patients.

Tan Jun Rong JR Tan Kay Sin KS Koo Yu Xuan YX Yong Fung Lin FL Wang Chee Woon CW Armugam Arunmozhiarasi A Jeyaseelan Kandiah K

International journal of molecular sciences 20130122 1

Ischemic stroke is a multi-factorial disease where some patients present themselves with little or no risk factors. Blood microRNA expression profiles are becoming useful in the diagnosis and prognosis of human diseases. We therefore investigated the blood microRNA profiles in young stroke patients who presented with minimal or absence of risk factors for stroke such as type 2 diabetes, dyslipidemia and hypertension. Blood microRNA profiles from these patients varied with stroke subtypes as well ...[more]

PMID: 23340648

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