Ontology highlight
ABSTRACT:
SUBMITTER: Dietz DM
PROVIDER: S-EPMC3565539 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Dietz David M DM Sun Haosheng H Lobo Mary Kay MK Cahill Michael E ME Chadwick Benjamin B Gao Virginia V Koo Ja Wook JW Mazei-Robison Michelle S MS Dias Caroline C Maze Ian I Damez-Werno Diane D Dietz Karen C KC Scobie Kimberly N KN Ferguson Deveroux D Christoffel Daniel D Ohnishi Yoko Y Hodes Georgia E GE Zheng Yi Y Neve Rachael L RL Hahn Klaus M KM Russo Scott J SJ Nestler Eric J EJ
Nature neuroscience 20120601 6
Repeated cocaine administration increases the dendritic arborization of nucleus accumbens neurons, but the underlying signaling events remain unknown. Here we show that repeated exposure to cocaine negatively regulates the active form of Rac1, a small GTPase that controls actin remodeling in other systems. Further, we show, using viral-mediated gene transfer, that overexpression of a dominant negative mutant of Rac1 or local knockout of Rac1 is sufficient to increase the density of immature dend ...[more]