Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Z
PROVIDER: S-EPMC3566120 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Zhu Zixiang Z Shi Zixue Z Yan Wenjun W Wei Jianchao J Shao Donghua D Deng Xufang X Wang Shaohui S Li Beibei B Tong Guangzhi G Ma Zhiyong Z
PloS one 20130206 2
Human guanylate-binding protein 1 (hGBP1) is an interferon-inducible protein involved in the host immune response against viral infection. In response to infection by influenza A virus (IAV), hGBP1 transcript and protein were significantly upregulated. Overexpression of hGBP1 inhibited IAV replication in a dose-dependent manner in vitro. The lysine residue at position 51 (K51) of hGBP1 was essential for inhibition of IAV replication. Mutation of K51 resulted in an hGBP1 that was unable to inhibi ...[more]