Tricyclic Benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cells.
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ABSTRACT:
SUBMITTER: Kiriazis A
PROVIDER: S-EPMC3566155 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Tricyclic Benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cells.
Kiriazis Alexandros A Vahakoski Riitta L RL Santio Niina M NM Arnaudova Ralica R Eerola Sini K SK Rainio Eeva-Marja EM Aumüller Ingo B IB Yli-Kauhaluoma Jari J Koskinen Päivi J PJ
PloS one 20130206 2
Oncogenic Pim family kinases are often overexpressed in human hematopoietic malignancies as well as in solid tumours. These kinases contribute to tumorigenesis by promoting cell survival and by enhancing resistance against chemotherapy and radiation therapy. Furthermore, we have recently shown that they increase the metastatic potential of adherent cancer cells. Here we describe identification of tricyclic benzo[cd]azulenes and their derivatives as effective and selective inhibitors of Pim kinas ...[more]
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