Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe H
PROVIDER: S-EPMC3566312 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Watanabe Hideo H Francis Joshua M JM Woo Michele S MS Etemad Banafsheh B Lin Wenchu W Fries Daniel F DF Peng Shouyong S Snyder Eric L EL Tata Purushothama Rao PR Izzo Francesca F Schinzel Anna C AC Cho Jeonghee J Hammerman Peter S PS Verhaak Roel G RG Hahn William C WC Rajagopal Jayaraj J Jacks Tyler T Meyerson Matthew M
Genes & development 20130115 2
The NKX2-1 transcription factor, a regulator of normal lung development, is the most significantly amplified gene in human lung adenocarcinoma. To study the transcriptional impact of NKX2-1 amplification, we generated an expression signature associated with NKX2-1 amplification in human lung adenocarcinoma and analyzed DNA-binding sites of NKX2-1 by genome-wide chromatin immunoprecipitation. Integration of these expression and cistromic analyses identified LMO3, itself encoding a transcription r ...[more]