Ontology highlight
ABSTRACT:
SUBMITTER: Min HJ
PROVIDER: S-EPMC3566580 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Min Hyun Jin HJ Ko Eun Ae EA Wu Jie J Kim Eun Sung ES Kwon Min Kyung MK Kwak Man Sup MS Choi Ji Eun JE Lee Jong Eun JE Shin Jeon-Soo JS
Journal of immunology (Baltimore, Md. : 1950) 20130109 4
High-mobility group box 1 protein (HMGB1), which mainly exists in the nucleus, has recently been shown to function as a sentinel molecule for viral nucleic acid sensing and an autophagy regulator in the cytoplasm. In this study, we studied the chaperone-like activity of HMGB1 and found that HMGB1 inhibited the chemically induced aggregation of insulin and lysozyme, as well as the heat-induced aggregation of citrate synthase. HMGB1 also restored the heat-induced suppression of cytoplasmic lucifer ...[more]