Ontology highlight
ABSTRACT:
SUBMITTER: Moore TW
PROVIDER: S-EPMC3566758 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20130130
High-throughput screening (HTS) previously identified benzimidazole 1 (JMN3-003) as a compound with broad antiviral activity against different influenza viruses and paramyxovirus strains. In pursuit of a lead compound from this series for development, we sought to increase both the potency and the aqueous solubility of 1. Lead optimization has achieved compounds with potent antiviral activity against a panel of myxovirus family members (EC(50) values in the low nanomolar range) and much improved ...[more]