Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker.
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ABSTRACT:
SUBMITTER: Collot M
PROVIDER: S-EPMC3566856 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker.
Collot Mayeul M Eller Steffen S Weishaupt Markus M Seeberger Peter H PH
Beilstein journal of organic chemistry 20130116
Automated oligosaccharide assembly requires suitable linkers to connect the first monosaccharide to a solid support. A new hydrogenolysis-labile linker that is stable under both acidic and basic conditions was designed, synthesized and coupled to different resins. Glycosylation and cleavage efficiencies on these functionalized solid supports were investigated, and restrictions for the choice of solid support for oligosaccharide synthesis were found. ...[more]
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