Ontology highlight
ABSTRACT:
SUBMITTER: Luo Z
PROVIDER: S-EPMC3567027 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Luo Zheng Z Liu Huimin H Sun Xiaomeng X Guo Rong R Cui Ruibing R Ma Xiangxing X Yan Ming M
PloS one 20130207 2
Discoidin domain receptor 2 (DDR2) is involved in fibrotic disease. However, the exact pathogenic implications of the receptor in early alcoholic liver disease are still controversial. We constructed plasmid vectors encoding short-hairpin RNA against DDR2 to investigate its role in alcoholic liver disease in an immortalized rat hepatic stellate cell line, HSC-T6, and in rats by MTT, RT-PCR and western blot analyses; immunohistochemistry and electron microscopy. Alcohol-induced upregulation of DD ...[more]