Ontology highlight
ABSTRACT:
SUBMITTER: Plovanich M
PROVIDER: S-EPMC3567112 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Plovanich Molly M Bogorad Roman L RL Sancak Yasemin Y Kamer Kimberli J KJ Strittmatter Laura L Li Andrew A AA Girgis Hany S HS Kuchimanchi Satya S De Groot Jack J Speciner Lauren L Taneja Nathan N Oshea Jonathan J Koteliansky Victor V Mootha Vamsi K VK
PloS one 20130207 2
Mitochondrial calcium uptake is present in nearly all vertebrate tissues and is believed to be critical in shaping calcium signaling, regulating ATP synthesis and controlling cell death. Calcium uptake occurs through a channel called the uniporter that resides in the inner mitochondrial membrane. Recently, we used comparative genomics to identify MICU1 and MCU as the key regulatory and putative pore-forming subunits of this channel, respectively. Using bioinformatics, we now report that the huma ...[more]