Ontology highlight
ABSTRACT:
SUBMITTER: Valente LP
PROVIDER: S-EPMC3567493 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Valente Luis P LP Dehé Pierre-Marie PM Klutstein Michael M Aligianni Sofia S Watt Stephen S Bähler Jürg J Cooper Julia Promisel JP
The EMBO journal 20130111 3
The TTAGGG motif is common to two seemingly unrelated dimensions of chromatin function-the vertebrate telomere repeat and the promoter regions of many Schizosaccharomyces pombe genes, including all of those encoding canonical histones. The essential S. pombe protein Teb1 contains two Myb-like DNA binding domains related to those found in telomere proteins and binds the human telomere repeat sequence TTAGGG. Here, we analyse Teb1 binding throughout the genome and the consequences of reduced Teb1 ...[more]