Ontology highlight
ABSTRACT:
SUBMITTER: Nishino T
PROVIDER: S-EPMC3567495 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Nishino Tatsuya T Rago Florencia F Hori Tetsuya T Tomii Kentaro K Cheeseman Iain M IM Fukagawa Tatsuo T
The EMBO journal 20130118 3
The kinetochore forms a dynamic interface with microtubules from the mitotic spindle during mitosis. The Ndc80 complex acts as the key microtubule-binding complex at kinetochores. However, it is unclear how the Ndc80 complex associates with the inner kinetochore proteins that assemble upon centromeric chromatin. Here, based on a high-resolution structural analysis, we demonstrate that the N-terminal region of vertebrate CENP-T interacts with the 'RWD' domain in the Spc24/25 portion of the Ndc80 ...[more]