Maternal antidepressant use and adverse outcomes: a cohort study of 228,876 pregnancies.

ABSTRACT:

Objective

The purpose of this study was to describe antidepressant medication use patterns during pregnancy and pregnancy outcomes.

Study design

We evaluated a cohort of 228,876 singleton pregnancies that were covered by Tennessee Medicaid, 1995-2007.

Results

Of 23,280 pregnant women with antidepressant prescriptions before pregnancy, 75% of them filled none in the second or third trimesters of pregnancy, and 10.7% of them used antidepressants throughout pregnancy. Filling 1, 2, and ≥3 antidepressant prescriptions during the second trimester was associated with shortened gestational age by 1.7 (95% confidence interval [CI], 1.2-2.3), 3.7 (95% CI, 2.8-4.6), and 4.9 (95% CI, 3.9-5.8) days, when controlled for measured confounders. Third-trimester selective serotonin reu

SUBMITTER: Hayes RM 

PROVIDER: S-EPMC3567615 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature