Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC3567659 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Li Sheng S Zhou Qibing Q He Huan H Zhao Yahui Y Liu Zhihua Z
The Journal of biological chemistry 20121228 6
Peroxisome proliferator-activated receptor γ (PPARγ), a subgroup of ligand-activated nuclear receptors, plays critical roles in cell cycle regulation, differentiation, apoptosis, and invasion. PPARγ is involved in tumorigenesis and is a potent target for cancer therapy. PPARγ transactivation of KLF4 has been demonstrated in various studies; however, how PPARγ regulates KLF4 expression is not clear. In this study, we reveal that PPARγ regulates the expression of KLF4 by binding directly to the PP ...[more]