Ontology highlight
ABSTRACT:
SUBMITTER: Yan H
PROVIDER: S-EPMC3568119 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130208 2
Since accumulating evidence suggests the application of anesthetics may increase the risk of Alzheimer's disease (AD), we investigated the cytotoxicity of inhaled general anesthesia in neurons and its underlying mechanism. Using primary cultured rat hippocampal neurons as the study model, here we show that isoflurane increases vulnerability to intracellular or extracellular amyloid β with or without serum deprivation. This isoflurane-induced effect is mediated by the downregulation of miR-214 le ...[more]