Unknown

Dataset Information

0

Prevalence and predictors of prescription psychoactive medication use in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.


ABSTRACT: Childhood cancer survivors are at risk for late effects which may be managed pharmacologically. The purposes of this study were to estimate and compare the prevalence of psychoactive medication use of adult survivors of childhood cancer and sibling controls, identify predictors of medication use in survivors, and investigate associations between psychoactive medications and health-related quality of life (HRQOL).Psychoactive medication use from 1994 to 2010 was evaluated in 10,378 adult survivors from the Childhood Cancer Survivor Study. A randomly selected subset of 3,206 siblings served as a comparison group. Multivariable logistic regression models were used to calculate odds ratios (OR) for baseline and new onset of self-reported psychoactive medication use and HRQOL.Survivors were significantly more likely to report baseline (22 vs. 15 %, p?15 years following diagnosis. Antidepressants were associated with impairment across all domains of HRQOL, with the exception of physical function.Prevalence of psychoactive medication use was higher among survivors for most medication classes, as was the use of multiple medications. Clinicians should be aware of the possible contribution of psychoactive medications to HRQOL.Survivors of childhood cancer are more likely to be prescribed psychoactive medication than their sibling counterparts, though use of such medication does not appear to normalize quality of life. Survivors are encouraged to consider additional interventions, including psychosocial support and physical exercise.

SUBMITTER: Brinkman TM 

PROVIDER: S-EPMC3568188 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Prevalence and predictors of prescription psychoactive medication use in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

Brinkman Tara M TM   Ullrich Nicole J NJ   Zhang Nan N   Green Daniel M DM   Zeltzer Lonnie K LK   Lommel Karen M KM   Brouwers Pim P   Srivastava Deo Kumar DK   Jain Neelam N   Robison Leslie L LL   Krull Kevin R KR  

Journal of cancer survivorship : research and practice 20121208 1


<h4>Purpose</h4>Childhood cancer survivors are at risk for late effects which may be managed pharmacologically. The purposes of this study were to estimate and compare the prevalence of psychoactive medication use of adult survivors of childhood cancer and sibling controls, identify predictors of medication use in survivors, and investigate associations between psychoactive medications and health-related quality of life (HRQOL).<h4>Methods</h4>Psychoactive medication use from 1994 to 2010 was ev  ...[more]

Similar Datasets

| S-EPMC3494805 | biostudies-literature
| S-EPMC7583158 | biostudies-literature
| S-EPMC3091978 | biostudies-literature
| S-EPMC4992459 | biostudies-literature
| S-EPMC3428202 | biostudies-literature
| S-EPMC4879056 | biostudies-literature
| S-EPMC2783513 | biostudies-literature
| S-EPMC4545345 | biostudies-literature
| S-EPMC6054538 | biostudies-literature
| S-EPMC3423483 | biostudies-literature