Stability of polymorphic GC-rich repeat sequence-containing regions of Mycobacterium tuberculosis.
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ABSTRACT:
SUBMITTER: Richardson M
PROVIDER: S-EPMC356821 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Publications
Stability of polymorphic GC-rich repeat sequence-containing regions of Mycobacterium tuberculosis.
Richardson Madalene M van der Spuy Gian D GD Sampson Samantha L SL Beyers Nulda N van Helden Paul D PD Warren Robin M RM
Journal of clinical microbiology 20040301 3
Mycobacterium tuberculosis cultures were subjected to DNA fingerprinting with IS6110- and polymorphic GC-rich sequence (PGRS)-containing probes. The PGRS banding patterns remained highly stable during multiple cultures of specimens from one disease episode (0.5% changed) and during transmission in patients with close contact (1.9% changed). Characteristic PGRS-restriction fragment length polymorphism motifs for different strain groupings may indicate distant evolutionary events leading to the di ...[more]
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