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Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota.


ABSTRACT: Alterations in the diversity of the gut microbiota are believed to underlie the development of antibiotic-associated diarrhea (AAD). A molecular phylogenetic analysis was performed to document temporal changes in the diversity of fecal bacteria of a patient who developed AAD. Antibiotic administration was associated with distinct changes in the diversity of the gut microbiota, including a marked decrease in the prevalence of butyrate-producing bacteria. Following the discontinuation of the antibiotic, resolution of diarrhea was accompanied by a reversal of these changes, providing the first direct evidence linking changes in the community structure of the gastrointestinal bacteria with the development of AAD.

SUBMITTER: Young VB 

PROVIDER: S-EPMC356823 | biostudies-literature | 2004 Mar

REPOSITORIES: biostudies-literature

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Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota.

Young Vincent B VB   Schmidt Thomas M TM  

Journal of clinical microbiology 20040301 3


Alterations in the diversity of the gut microbiota are believed to underlie the development of antibiotic-associated diarrhea (AAD). A molecular phylogenetic analysis was performed to document temporal changes in the diversity of fecal bacteria of a patient who developed AAD. Antibiotic administration was associated with distinct changes in the diversity of the gut microbiota, including a marked decrease in the prevalence of butyrate-producing bacteria. Following the discontinuation of the antib  ...[more]

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