Ontology highlight
ABSTRACT:
SUBMITTER: Tomasetti C
PROVIDER: S-EPMC3568331 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Tomasetti Cristian C Vogelstein Bert B Parmigiani Giovanni G
Proceedings of the National Academy of Sciences of the United States of America 20130123 6
Although it has been hypothesized that some of the somatic mutations found in tumors may occur before tumor initiation, there is little experimental or conceptual data on this topic. To gain insights into this fundamental issue, we formulated a mathematical model for the evolution of somatic mutations in which all relevant phases of a tissue's history are considered. The model makes the prediction, validated by our empirical findings, that the number of somatic mutations in tumors of self-renewi ...[more]