Ontology highlight
ABSTRACT:
SUBMITTER: Xiang J
PROVIDER: S-EPMC3568392 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Virology 20120516 1
GB virus C (GBV-C) infection is associated with prolonged survival in HIV-infected cohorts, and GBV-C E2 protein inhibits HIV entry when added to CD4+ T cells. To further characterize E2 effects on HIV replication, stably transfected Jurkat cell lines expressing GBV-C E2 or control sequences were infected with HIV and replication was measured. HIV replication (all 6 isolates studied) was inhibited in all cell lines expressing a region of 17 amino acids of GBV-C E2, but not in cell lines expressi ...[more]