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ABSTRACT:
SUBMITTER: Rodriguez-Moya J
PROVIDER: S-EPMC3568561 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Rodríguez-Moya Javier J Argandoña Montserrat M Iglesias-Guerra Fernando F Nieto Joaquín J JJ Vargas Carmen C
Applied and environmental microbiology 20121116 3
Hydroxyectoine overproduction by the natural producer Chromohalobacter salexigens is presented in this study. Genetically engineered strains were constructed that at low salinity coexpressed, in a vector derived from a native plasmid, the ectoine (ectABC) and hydroxyectoine (ectD) genes under the control of the ectA promoter, in a temperature-independent manner. Hydroxyectoine production was further improved by increasing the copies of ectD and using a C. salexigens genetic background unable to ...[more]