MicroRNAs in age-related diseases.
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ABSTRACT:
SUBMITTER: Dimmeler S
PROVIDER: S-EPMC3569636 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
MicroRNAs in age-related diseases.
Dimmeler Stefanie S Nicotera Pierluigi P
EMBO molecular medicine 20130122 2
Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders. MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally control gene expression by inhibiting translation or inducing degradation of targeted mRNAs. MiRNAs target up to hundreds of mRNAs, thereby modulating gene expression patterns. Many miRNAs appear to be dysregulated during cellular senescence, agin ...[more]
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