Ontology highlight
ABSTRACT:
SUBMITTER: Moreira Sousa C
PROVIDER: S-EPMC3569645 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Moreira Sousa Cristovão C McGuire John Russel JR Thion Morgane Sonia MS Gentien David D de la Grange Pierre P Tezenas du Montcel Sophie S Vincent-Salomon Anne A Durr Alexandra A Humbert Sandrine S
EMBO molecular medicine 20130109 2
In Huntington disease (HD), polyglutamine expansion in the huntingtin protein causes specific neuronal death. The consequences of the presence of mutant huntingtin in other tissues are less well understood. Here we propose that mutant huntingtin influences breast cancer progression. Indeed, we show that mammary tumours appear earlier in mouse breast cancer models expressing mutant huntingtin as compared to control mice expressing wild-type huntingtin. Tumours bearing mutant huntingtin have a mod ...[more]