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Itpr3 Is responsible for the mouse tufted (tf) locus.


ABSTRACT: The tf (tufted) locus is responsible for a classic phenotype of hair loss and regrowth in mice. It is a characteristic of the BTBR strain. Here, we use a combination of positional cloning methods and complementation mapping to identify Itpr3, the inositol triphosphate receptor type 3, as the gene responsible for the tf locus.

SUBMITTER: Ellis HT 

PROVIDER: S-EPMC3570182 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Itpr3 Is responsible for the mouse tufted (tf) locus.

Ellis Hillary T HT   Tordoff Michael G MG   Parker M Rockwell MR  

The Journal of heredity 20121025 2


The tf (tufted) locus is responsible for a classic phenotype of hair loss and regrowth in mice. It is a characteristic of the BTBR strain. Here, we use a combination of positional cloning methods and complementation mapping to identify Itpr3, the inositol triphosphate receptor type 3, as the gene responsible for the tf locus. ...[more]

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