Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques.

ABSTRACT: Clinical isolates of Helicobacter pylori show marked diversity, which may derive from genomic changes that occur during the often lifelong association of the bacterium with its human host. We used the rhesus macaque model, together with DNA microarrays, to examine genomic changes in H. pylori that occur early during experimental infection. Microarray analysis showed that H. pylori recovered from challenged macaques had deleted babA, a member of a large family of paralogous outer membrane proteins (OMPs) that mediates attachment of H. pylori to the Lewis B blood group antigen on gastric epithelium. In some cases the babA gene was replaced by babB, an uncharacterized OMP that is closely related to babA. In other cases the babA gene was present but was not expressed because of alteration in d

SUBMITTER: Solnick JV 

PROVIDER: S-EPMC357059 | biostudies-literature | 2004 Feb

REPOSITORIES: biostudies-literature