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Complete genome sequence of Treponema pallidum strain DAL-1.

ABSTRACT: Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.

SUBMITTER: Zobanikova M

PROVIDER: S-EPMC3570794 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Complete genome sequence of Treponema pallidum strain DAL-1.

Zobaníková Marie M Mikolka Pavol P Cejková Darina D Pospíšilová Petra P Chen Lei L Strouhal Michal M Qin Xiang X Weinstock George M GM Smajs David D

Standards in genomic sciences 20120924 1

Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the comple ...[more]

PMID: 23449808

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