Adaptively weighted association statistics.
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ABSTRACT:
SUBMITTER: LeBlanc M
PROVIDER: S-EPMC3571103 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Adaptively weighted association statistics.
LeBlanc Michael M Kooperberg Charles C
Genetic epidemiology 20090701 5
We investigate methods for testing gene-disease outcome associations in situations where the genetic relationship potentially varies among subjects with differing environmental or clinical attributes. We propose a strategy which modestly increases multiple testing by evaluating weighted test statistics which focus (or enrich) association tests within subgroups and use a Monte-Carlo method, based on simulating from the approximate large sample distribution of the statistics, to control type 1 err ...[more]
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