Ontology highlight
ABSTRACT:
SUBMITTER: Jang ES
PROVIDER: S-EPMC3571620 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Jang Eue-Soon ES Shin June-Ho JH Ren Gang G Park Mi-Jin MJ Cheng Kai K Chen Xiaoyuan X Wu Joseph C JC Sunwoo John B JB Cheng Zhen Z
Biomaterials 20120508 22
The present work demonstrates that Cy5.5 conjugated Fe(3)O(4)/SiO(2) core/shell nanoparticles could allow us to control movement of human natural killer cells (NK-92MI) by an external magnetic field. Required concentration of the nanoparticles for the cell manipulation is as low as ~20 μg Fe/mL. However, the relative ratio of the nanoparticles loaded NK-92MI cells infiltrated into the target tumor site is enhanced by 17-fold by applying magnetic field and their killing activity is still maintain ...[more]