Connexins and the atrioventricular node.
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ABSTRACT:
SUBMITTER: Temple IP
PROVIDER: S-EPMC3572393 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Connexins and the atrioventricular node.
Temple Ian P IP Inada Shin S Dobrzynski Halina H Boyett Mark R MR
Heart rhythm 20121022 2
The structure and functioning of the atrioventricular (AV) node has remained mysterious owing to its high degree of complexity. In this review article, we integrate advances in knowledge regarding connexin expression in the AV node. Complex patterning of 4 different connexin isoforms with single channel conductances ranging from ultralow to high explains the dual pathway electrophysiology of the AV node, the presence of 2 nodal extensions, longitudinal dissociation in the penetrating bundle, and ...[more]
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