Ontology highlight
ABSTRACT:
SUBMITTER: Salathia NS
PROVIDER: S-EPMC3572451 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Salathia Neeraj S NS Shi Jian J Zhang Jay J Glynne Richard J RJ
The Journal of investigative dermatology 20121025 3
Skin wounds comprise a serious medical issue for which few pharmacological interventions are available. Moreover, the inflammatory, angiogenic, and proliferative facets of a typical response to a wound each have broader relevance in other pathological conditions. Here we describe a genomics-driven approach to identify secreted proteins that modulate wound healing in a mouse ear punch model. We show that adiponectin, when injected into the wound edge, accelerates wound healing. Notably, adiponect ...[more]