Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC3572910 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Wang Yaming Y Swiecki Melissa M Cella Marina M Alber Gottfried G Schreiber Robert D RD Gilfillan Susan S Colonna Marco M
Cell host & microbe 20120601 6
Type I interferon (IFN-I) promotes antiviral CD8(+)T cell responses, but the contribution of different IFN-I sources and signaling pathways are ill defined. While plasmacytoid dendritic cells (pDCs) produce IFN-I upon TLR stimulation, IFN-I is induced in most cells by helicases like MDA5. Using acute and chronic lymphocytic choriomeningitis virus (LCMV) infection models, we determined that pDCs transiently produce IFN-I that minimally impacts CD8(+)T cell responses and viral persistence. Rather, ...[more]