Ontology highlight
ABSTRACT:
SUBMITTER: Barquero-Calvo E
PROVIDER: S-EPMC3573106 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Barquero-Calvo Elías E Martirosyan Anna A Ordoñez-Rueda Diana D Arce-Gorvel Vilma V Alfaro-Alarcón Alejandro A Lepidi Hubert H Malissen Bernard B Malissen Marie M Gorvel Jean-Pierre JP Moreno Edgardo E
PLoS pathogens 20130214 2
Polymorphonuclear neutrophils (PMNs) are the first line of defense against microbial pathogens. In addition to their role in innate immunity, PMNs may also regulate events related to adaptive immunity. To investigate the influence of PMNs in the immune response during chronic bacterial infections, we explored the course of brucellosis in antibody PMN-depleted C57BL/6 mice and in neutropenic mutant Genista mouse model. We demonstrate that at later times of infection, Brucella abortus is killed mo ...[more]