Ontology highlight
ABSTRACT:
SUBMITTER: Gow DJ
PROVIDER: S-EPMC3573236 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Gow Deborah J DJ Garceau Valerie V Pridans Clare C Gow Adam G AG Simpson Kerry E KE Gunn-Moore Danielle D Hume David A DA
Cytokine 20121219 2
Colony stimulating factor (CSF-1) and its receptor, CSF-1R, have been previously well studied in humans and rodents to dissect the role they play in development of cells of the mononuclear phagocyte system. A second ligand for the CSF-1R, IL-34 has been described in several species. In this study, we have cloned and expressed the feline CSF-1R and examined the responsiveness to CSF-1 and IL-34 from a range of species. The results indicate that pig and human CSF-1 and human IL-34 are equally effe ...[more]